Nuclear Magnetic Resonance (NMR) includes a set of non-invasive techniques, which can be sensitized to many phenomena of biomedical interest. These include blood perfusion, metabolic and molecular dynamics, water diffusion, and many others. These properties allowed the establishment of MR Imaging and Spectroscopy as important techniques for the study of the brain function and structure and of the relevant diseases. Furthermore, MR development resulted in a large everyday-life impact, including advanced diagnostic tools.
Beyond its capability to produce excellent tomographic imaging of the central nervous system, NMR can be exploited quantitatively, given that the sample magnetization can be manipulated in order to obtain a signal capable of mapping one or several physical or chemical parameters of the sample itself.
Activity of our Laboratory are focused on several topics that can be gathered together in two major topics. First, the development of MR techniques and of the relevant processing methods, mainly in the fields of spectroscopy and quantitative imaging. Second, the use of these tailored techniques in some fields of great interest for the applied sciences, related to the physiology and pathology of human brain function. These embrace the brain metabolic dynamics and the changes of brain functional networks induced by physiologic activity or pathology.